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Über das RTC Stammzelltherapie Forschung Translation Service/Technologietransfer Kontakt
Stammzellforschung und
kardiale Regeneration
Entwicklung von Technologien zur Stammzellmodifikation
Klinische Studien
Publikationen
Patente

2017

PubMed-ID

Müller, P.,Gäbel R., Lemcke H., Wiekhorst F., Hausburg F., Lang C., Zarniko N., Westphal B., Steinhoff G., David R.

Intramyocardial fate and effect of iron nanoparticles co-injected with MACS®purified stem cell products Biomaterials 2017 Aug; 135:74-84. doi: 10.1016/j.biomaterials.2017.05.002  . Epub 2017 May 4.

28494265

Voronina N., Lemcke H., Wiekhorst F., Kühne J.-P., Frank M., Steinhoff G., David R.

Preparation and In Vitro Characterization of Megnetized miR-modified Endothelial CellsJoVE 05/02/2017, Issue 123 (/archive123); doi: 10.3791/55567 

 

Ziegler T, Hinkel R, Stöhr A, Eschenhagen T, Laugwitz K-L, Le Noble F, David R, Hansen A, Kupatt C

Thymosin ß4 improves differentiation and vascularization of EHTs STEM CELLS INTERNATIONAL 2017; 2017:6848271.doi10.1155/2017/6848271

28191018

Nesteruk I, Voronina N, Kundt G, Donndorf P, Klopsch C, Kaminski A, Duckers HJ, Steinhoff G

Stem Cell registry program for patients with ischemic cardiomyopathy undergoing CABG: what benefits does it derive? ESC HEART FAILURE 2017 May;4(2):105-111.doi: 10.1002/ehf2.12132       
28451446

Skorska A, Müller P, Gaebel R, Große J, Lemcke H, Lux CA, Bastian M, Hausburg F, Zarniko N, Bubritzki S, Ruch U, Tiedemann G, David R, Steinhoff G

GMP-conform on-site manufacturing of a CD133+ stem cell product for cardiovascular regeneration STEM CELL RESEARCH & THERAPY (accepted)

28187777

2016

 

Nesteruk, J.

Regenerative Medicine - from Protocol to Patient Bd. 5 Regenerative Therapies Kapitel "Heart" (S. 59-109) SPRINGER INTERNATIONAL PUBLISHING SWITZERLAND

Buchbeitrag

Brenner, Ch., David R., Franz W.-M.

Regenerative Medicine - from Protocol to Patient Bd. 2 Stem Cell Science and Technology Kapitel "Stem Cells for Cardiovascular Regeneration" (S.145-167) SPRINGER INTERNATIONAL PUBLISHING SWITZERLAND

Buchbeitrag

Jana Große, Ulrike Ruch und Gudrun Tiedemann

"Qualitätsmanagement bei neu gegründeten Life-Science-Unternehmen"

In: Jochen Becker und Thomas R. Villinger (Hrsg.) LIFE SCIENCE VENTURING 2017 Springer Gabler Wiesbaden

 

Buchbeitrag

Prinz B, Harvey KL, Wilcke L, Ruch U, Engelberg K, Biller L, Lucet I, Erkelenz S, Heincke D, Spielmann T, Doerig C, Kunick C, Crabb BS, Gilson PR, Gilberger TW

Hierarchial phosphprylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites SCI REP. 2016; 6: 34479

27698395

Lemcke H, Voronina N, Steinhoff G, David R

Analysis of the gap junction-dependent transfer of miRNA by 3D-FRAP microscopy JoVE (accepted)

 

Steinhoff G (Herausgeber)

Regenerative Medicine - from Protocol to Patient (Third Edition) SPRINGER INTERNATIONAL PUBLISHING SWITZERLAND

Sammelband

Voronina N, Lemcke H, Wiekhorst F, Kühn JP, Steinhoff G, David R

Manufacturing and in vitro characterization of magnetized miR-modified endothelial cells for regenerative medicine JoVE (accepted)

 

Voronina N, Lemcke H, Wiekhorst F, Kühn JP, Rimmbach C, Steinhoff G, David R

Non-viral magnetic engineering of endothelial cells wirh microrNA and plasmid-DNA - An optimized targeting approach NANOMEDICINE 2016 Nov; 12(8): 2353-2364

27389150

Lemcke H, Peukert J, Voronina N, Skorska A, Steinhoff G, David R

Applying 3D-FRAP microscopy to analyse gap junction-dependent shuttling of small antisense RNAs between cardiomyocytes J MOL CELL Cardiol 2016 Sep; 98: 117-27

27480520

Müller P, Voronina N, Hausburg F, Lux CA, Wiekhorst F, Steinhoff G, David R

Magnet-Bead Based MicroRNA Delivery System to Modify CD133+ - Stem Cells STEM CELLS INT 2016; 2016:7152761

27795713

2015

PubMed-ID

Dusl M, Senderek j, Müller JS, Vogel JG, Pertl A, Stucka R, Lochmüller H, David R, Abicht A

A3-UTR Mutation creates a microRNA target site in the GFPT1 gene of patients with congenital myasthenic syndrome HUMAN MOLECULAR GENETICS;S:3418-3426

25765662

Donndorf P, Lube L, Lux C, Skorska A, Steinhoff G, Kraft K

Mobilization of Bone Marrow-Derived Endothelial Progenitor Cells Finnish Sauna: A Pilot Study FORSCH KOMPLEMENTMED; S:246-250

26565406

Lang CI, Krause BJ, David R

Cardiac FDG-PET: a straight forward tool with high potential EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING

26510929

Rimmbach C, Jung JJ, David R

Generation of murine cardiac pacemaker cell aggregates based on ES-cell-programming in combination with Myh6-promoter-selection JOVE-J VIS EXP; S: 52465-52465

25742394

Wolfien M, Rimmbach C, Schmitz U, Jung JJ, Krebs S, Steinhoff G, David R, Wolkenhauer O

TRAPLINE: a standardized and automated pipeline for RNA sequencing data analysis, evaluation and annotation BMC BIOINFORMATICS; S: 21-21

26738481

Donndorf P, Kaminski A

Gene-enhanced cell therapy for pulmonary arterial hypertehsion: Knocking at the clinical door? JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY; S. 632-633

26198129

Lauschke J, Schneider J, Schneider R, Nesselmann C, Tischer T, Glass A, Bänsch D

Electrophysiological studies in patients with paroxysmal supraventricular tachycardias but no electroardiogram documentation: findings from a prospective registry EUROPACE; S: 801-806

25926475

Tischer TS, Schneider R, Lauschke J, Nesselmann C, Klemm A, Diedrich D, Kundt G, Bänsch D

Prevalence of atrial fibrillation in patients with hogh CHADS2 -and CHA2DS2VASc-scores: anticoagulate or monitor high-risk patients? PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY; S: 1651-1657

25621351

Hausburg F, Na S, Voronina N, Skorska A, Müller P, Steinhoff G, David R

Defining optimized properties of modified mRNA to enhance virus- and DNA-independent protein expression in adult stem cells and fibroblasts CELLULAR PHYSIOLOGY AND BIOCHEMISTRY; S: 1360-1371

25720503

de Carvalho KA, Steinhoff G, Chachques JC

Mesenchymal stem cell therapy in nonhematopoietic diseases STEM CELLS INT; S 676903-676903

25815015

Lehner S, Lang C, Kaissis G, Todica A, Zacherl MJ Boening G, Spitzweg C, Herbach N, Franz WM, Krause BJ, Steinhoff G, Bartenstein P, Hacker M, David R

(124)I-PET Assessment of Human Sodium Iodide Symporter Reporter Gene Activity for Highly Sensitive In Vivo Monitoring of Teratoma Formation in Mice MOL IMAGING BIOL; S: 874-883

25896817

Chatzivasileiou K, Kriebel K, Steinhoff G, Kreikemeyer B, Lang H

Do oral bacteria alter the regenerative potential of stem cells? A concise review J CELL MOL MED; S: 2067-2074

26058313

Skorska A, von Haehling S, Ludwig M, Lux CA, Gaebel R, Kleiner G, Klopsch C, Dong J, Curato C, Altarche-Xifro W, Slavic S, Unger T, Steinhoff G, Li J, David R

The CD4(+) AT2R(+) T cell subpopulation improves post-infarction remodelling and restores cardiac function J CELL MOL MED; S:1975-1985

25991381

Alozie A, Zimpfer A, Köller K, Westphal B, Obliers A, Ebersdobler A, Steinhoff G, Podbielski A

Athralgia and blood culture -negative endocarditis in middle Age Men suggest tropheryma whipplei infection: report of two cases and review of the literature BMC INFECTIOUS DISEASES; S: 339-339

26282628

Alozie A, Köller K, Pose L, Raftis M, Steinhoff G, Westphal B, Lambrecht G, Podbielski A

Streptococcus bovis infectious endocarditis and occult gastrointestinal neoplasia: experience with 25 consecutive patients treated surgically GUT PATHOG; S: 27-27

26473016

Ludwig M, Tölk A, Skorska A, Maschmeier C, Gaebel R, Lux CA, Steinhoff G, David R

Exploiting AT2R to Improve CD117 Stem Cell Function In Vitro and In Vivo- Perspectives for Cardiac Stem Cell Therapy CELLULAR PHYSIOLOGY AND BIOCHEMISTRY; S: 77-93

26303045

Lemcke H, Steinhoff G, David R

Gap junctional shuttling of miRNA -A novel pathway of intercellular gene regulation and its prospects in clinical application CELLULAR SIGNALLING; S: 2506-2514

26391653

2014

PubMed-ID

Rimmbach C*, Jung JJ*, David R. Generation of murine cardiac pacemaker cell aggregates based on ES-cell-programming in combination with Myh6-promoter-selection. JoVE, in Press *Rimmbach C and *Jung J contributed equally to the manuscript 25742394
Prestin K, Wolf S, Feldtmann R, Hussner J, Geissler I, Rimmbach C, Kroemer HK, Zimmermann U, Zu Schwabedissen HE (2014).
Transcriptional regulation of urate transportosome member SLC2A9 by nuclear receptor HNF4alpha. American journal of physiology Renal physiology 307: F1041-1051
25209865
Meyer Zu Schwabedissen HE, Albers M, Baumeister SE, Rimmbach C, Nauck M, Wallaschofski H, Siegmund W, Volzke H, Kroemer HK (2014)
Function-impairing polymorphisms of the hepatic uptake transporter SLCO1B1 modify the therapeutic efficacy of statins in a population-based cohort. Pharmacogenetics and genomics
25379722
Knoll N, Jarick I, Volckmar AL, Klingenspor M, Illig T, Grallert H, Gieger C, Wichmann HE, Peters A, Wiegand S, Biebermann H, Fischer-Posovszky P, Wabitsch M, Volzke H, Nauck M, Teumer A, Rosskopf D, Rimmbach C, Schreiber S, Jacobs G, Lieb W, Franke A, Hebebrand J, Hinney A (2014)
Mitochondrial DNA variants in obesity. PloS one 9: e94882
24788344

Lang C, Lehner S, Todica A, Boening G, Zacherl M, Franz WM, Krause BJ, Bartenstein P, Hacker M**, David R**. In-vivo comparison of the acute retention of stem cell derivatives and fibroblasts after intramyocardial transplantation in the mouse model. Eur J Nucl Med Mol Imaging. 2014 Jul 26. [Epub ahead of print] ** M. Hacker and R. David share senior authorship.

25063040
Grabmaier U*, Brandl L*, Kreiner J, Negele T, Huber BC, Rimmbach C, David R, Brunner S (2014). Increased Numbers Of Bone Marrow-Derived Cells In Parathyroid Adenoma. Eur J Clin Invest. 44:833-839. * U. Grabmaier and L. Brandl contributed equally to the manuskript. 25047264
Alozie A, Westphal B, Kische S, Kaminski A, Paranskaya L, Bozdag-Turan I, Ortak J, Schubert J, Steinhoff G, Ince H. (2014). Surgical revision after percutaneous mitral valve repair by edge-to-edge device: when the strategy fails in the highest risk surgical population. Eur J Cardiothorac Surg. 46(1):55-60. 24321993
Alozie A*, Kische S*, Birken T*, Kaminski A, Westphal B, Nöldge-Schomburg G, Ince H, Steinhoff G. Awake Extracorporeal Membrane Oxygenation (ECMO) as Bridge to Recovery After Left Main Coronary Artery Occlusion: A Promising Concept of Haemodynamic Support in Cardiogenic Shock. Heart Lung Circ. 2014 Jun 27. [Epub ahead of print] * A. Alozie, S. Kische and T. Birken contributed equally to the manuskript. 25043583
Donndorf P, Park H, Vollmar B, Alms A, Gierer P, Steinhoff G, Kaminski A. (2014). Impact of closed minimal extracorporeal circulation on microvascular tissue perfusion during surgical aortic valve replacement: intravital imaging in a prospective randomized study. Interact Cardiovasc Thorac Surg. 19(2):211-7.  24796334
Erben RG, Silva-Lima B, Reischl I, Steinhoff G, Tiedemann G, Dalemans W, Vos A, Janssen RT, Le Blanc K, van Osch G Phd, Luyten FP. White paper on how to go forward with cell-based Advanced Therapies in Europe. Tissue Eng Part A. 2014 Jun 3. [Epub ahead of print] 24749762
Jung J*, Husse B*, Rimmbach C*, Krebs S, Stieber J, Steinhoff G, Dendorfer A, Franz WM, David R. (2014). Programming and Isolation of Highly Pure Physiologically and Pharmacologically Functional Sinus-Nodal Bodies from Pluripotent Stem Cells.Stem Cell Reports. 2(5):592-605. * J. Jung, B. Husse and C. Rimmbach contributed equally to the manuskript. 24936448
Delyagina E, Schade A, Scharfenberg D, Skorska A, Lux C, Li W, Steinhoff G. (2014). Improved transfection in human mesenchymal stem cells: effective intracellular release of pDNA by magnetic polyplexes. Nanomedicine (Lond). 9(7):999-1017. 24063366
Lux CA*, Mark P*, Klopsch C, Laupheimer M, Tu-Rapp H, Li W, Ma N, Steinhoff G, David R. Impact of short-term liquid storage on human CD133+ stem cells. Cell Transplant. 2014 May 2 [Epub ahead of print] * C.A. Lux and P. Mark contributed equally to the manuskript. 24800805
Schade A*, Müller P*, Delyagina E, Voronina N, Skorska A, Lux C, Steinhoff G, David R. (2014). Magnetic Nanoparticle Based Nonviral MicroRNA Delivery into Freshly isolated CD105(+) hMSCs. Stem Cells Int. 2014:197154. * A. Schade and P. Müller contributed equally to the manuskript. 24799915
Steinhoff G. (2014). Re-growth of the adult heart by stem cells? Eur J Cardiothorac Surg. 45(1):6-9.  24188970
   

2013

PubMed-ID

Steinhoff G (Herausgeber)

Regenerative Medicine -from Protocol to Patient (Second edition) SPRINGER SCIENCE +BUSINESS MEDIA DORDRECHT

Sammelband
Xu Y*, Hu X*, Wang L, Jiang Z, Liu X, Yu H, Zhang Z, Chen H, Chen H, Steinhoff G, Li J, Jian'an Wang. (2013). Preconditioning via Angiotensin Type 2 Receptor Activation Improves Therapeutic Efficacy of Bone Marrow Mononuclear Cells for Cardiac Repair. PLoS One. 8(12):e82997. * Y. Xu and X. Hu contributed equally to the manuskript. 24340072
Donndorf P, Ludwig M, Wildschütz F, Useini D, Kaminski A, Vollmar B, Steinhoff G. (2013). Intravital microscopy of the microcirculation in the mouse cremaster muscle for the analysis of peripheral stem cell migration. J Vis Exp. (81):e50485. 24300446
Brunner S*, Theiss HD*, Leiss M, Grabmaier U, Grabmeier J, Huber B, Vallaster M, Clevert DA, Sauter M, Kandolf R, Rimmbach C, David R, Klingel K**, Franz WM**. (2013). Enhanced stem cell migration mediated by VCAM-1/VLA-4 interaction improves cardiac function in virus-induced dilated cardiomyopathy. Basic Res Cardiol. 108(6):388. * S. Brunner and H.D. Theiss contributed equally to the manuskript. ** K. Klingel and W.M. Franz share last authorship. 24065117
Mark P*, Kleinsorge M*, Gaebel R, Lux CA, Toelk A, Pittermann E, David R, Steinhoff G, Ma N. (2013). Human Mesenchymal Stem Cells Display Reduced Expression of CD105 after Culture in Serum-Free Medium. Stem Cells Int. 2013:698076. * P. Mark and M. Kleinsorge contributed equally to the manuskript. 24194767
Theiss HD*, Gross L*, Vallaster M, David R, Brunner S, Brenner C, Nathan P, Assmann G, Mueller-Hoecker J, Vogeser M, Steinbeck G, Franz WM. (2013). Antidiabetic gliptins in combination with G-CSF enhances myocardial function and survival after acute myocardial infarction. Int J Cardiol. 168(4):3359-69. * H.D. Theiss and L. Gross contributed equally to the manuskript. 23669105
Wang W, Li W, Ma N, Steinhoff G. (2013). Non-viral gene delivery methods. Curr Pharm Biotechnol. 14(1):46-60. 23437936
Donndorf P, Steinhoff G. (2013). CD133-Positive Cells for Cardiac Stem Cell Therapy: Current Status and Outlook. Adv Exp Med Biol. 777:215-27. 23161085
Wendeborn J, Donndorf P, Westphal B, Steinhoff G. (2013). Surgical double valve replacement after transcatheter aortic valve implantation and interventional mitral valve repair. Interact Cardiovasc Thorac Surg. 17(5):909-11. 23864579
Lang C*, Lehner S*, Todica A, Boening G, Franz WM, Bartenstein P, Hacker M**, David R**. (2013). Positron emission tomography based in-vivo imaging of early phase stem cell retention after intramyocardial delivery in the mouse model. Eur J Nucl Med Mol Imaging. 40(11):1730-8. * C. Lang and S. Lehner contributed equally to the manuskript. ** M. Hacker and R. David share last authorship. 23860738
Xu Y*, Hu X*, Wang L, Jiang Z, Liu X, Yu H, Zhang Z, Chen H, Chen H, Steinhoff G, Li J, Wang J. (2013). Transplantation of preconditioned bone marrow mononuclear cells by AT2R stimulation improves infarcted heart function via enhanced cardiac mobilization of implanted cells. Int J Cardiol. 168(4):4551-4. * Y. Xu and X. Hu contributed equally to the manuskript. 23870638
Buta C*, David R*, Dressel R*, Emgård M*, Fuchs C*, Gross U*, Healy L*, Hescheler J*, Kolar R*, Martin U*, Mikkers H*, Müller FJ*, Schneider RK*, Seiler AE*, Spielmann H*, Weitzer G*. (2013). Reconsidering pluripotency tests: do we still need teratoma assays? Stem Cell Res. 11(1):552-62. * all authors contributed equally to the manuskript. 23611953
Ludwig M, Skorska A, Tölk A, Hopp HH, Patejdl R, Li J, Steinhoff G, Noack T. (2013). Characterization of Ion Currents of Murine CD117pos Stem Cells in vitro and their modulation under AT2 R Stimulation. Acta Physiol (Oxf). 208(3):274-87. 23648269
Chatzivasileiou K, Lux CA, Steinhoff G, Lang H. (2013). Dental follicle progenitor cells responses to Porphyromonas gingivalis LPS. J Cell Mol Med. 17(6):766-73. 23560719
Schade A, Delyagina E, Scharfenberg D, Skorska A, Lux C, David R, Steinhoff G. (2013). Innovative Strategy for MicroRNA Delivery in Human Mesenchymal Stem Cells via Magnetic Nanoparticles. Int J Mol Sci. 14(6):10710-10726. 23702843
Nicetto D, Hahn M, Jung J, Schneider TD, Straub T, David R, Schotta G, Rupp RA. (2013). Suv4-20h histone methyltransferases promote neuroectodermal differentiation by silencing the pluripotency-associated Oct-25 gene. PLoS Genet. 9(1):e1003188. 23382689
Wolkenhauer O, Auffray C, Jaster R, Steinhoff G, Dammann O. (2013). The road from systems biology to systems medicine. Pediatr Res. 73(4 Pt 2):502-7. 23314297
Hartung S, Schwanke K, Haase A, David R, Franz WM, Martin U**, Zweigerdt R**. (2013). Directing cardiomyogenic differentiation of human pluripotent stem cells by plasmid-based transient overexpression of cardiac transcription factors. Stem Cells Dev. 1;22(7):1112-25. ** U. Martin and R. Zweigert contributed equally. 23157212
Donndorf P*, Useini D*, Lux CA, Vollmar B, Delyagina E, Laupheimer M, Kaminski A, Steinhoff G. (2013).  Analysing migratory properties of human CD 133+ - stem cells in vivo after intraoperative sternal bone marrow isolation. Cell Transplant. 22(9):1627-35. * P. Donndorf and D. Useini contributed equally to the manuskript. 23051098
Donndorf P, Bermaoui B, Westphal B, Steinhoff G. (2013). Asymptomatic blood cyst of the papillary muscle in an adult undergoing coronary bypass surgery. Interact Cardiovasc Thorac Surg. 16(3):402-4. 23223673
Kriegmair MC, Frenz S, Dusl M, Franz WM, David R, Rupp RA. (2013). Cardiac differentiation in Xenopus is initiated by mespa. Cardiovasc Res. 97(3):454-63. 23241315
Liu Y, Ye X, Mao L, Cheng Z, Yao X, Jia X, Mao D, Ou L, Li Z, Che Y, Liu N, Steinhoff G, Liu L, Kong D. (2013). Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction. Cardiovasc Res. 97(2):208-18.  23066088
David R, Schwarz F, Rimmbach C, Nathan P, Jung J, Brenner C, Jarsch V, Stieber J, Franz WM. (2013). Selection of a common multipotent cardiovascular stem cell using the 3.4-kb MesP1 promoter fragment. Basic Res Cardiol.108(1):312.   23184392
Donndorf P, Strauer BE, Haverich A, Steinhoff G. (2013). Stem Cell Therapy for the Treatment of Acute Myocardial Infarction and Chronic Ischemic Heart Disease. Curr Pharm Biotechnol. 14(1):12-9. 23092255
   

2012

PubMed-ID

Klopsch C, Gabel R, Kaminski A, Mark P, Wang W, Toelk A, Delyagina E, Kleiner G, Koch L, Chichkov B, Mela P, Jockenhoevel S, Ma N, Steinhoff G. (2012). Spray- and laser-assisted biomaterial processing for fast and efficient autologous cell-plus-matrix tissue engineering. J Tissue Eng Regen M. 23208947
Alozie A, Kaminski A, Donndorf P, Westphal B, Steinhoff G. (2012). Congenital quadricuspid aortic valve: a rare valvular pathology leading to aortic valve insufficiency. Heart Lung Circ. 21(3):193. 22227250
Alozie A, Westphal B, Yerebakan C, Steinhoff G. (2012). Bilateral Tension Pneumothoraces Leading to Cardiac Arrest after Coronary Artery Bypass Surgery. Thorac Cardiovasc Surg. 60 Suppl 2:e6-8. 22215502
Alozie A, Yerebakan C, Westphal B, Steinhoff G, Podbielski A. (2012). Culture-negative infective endocarditis of the aortic valve due to Aerococcus urinae: a rare aetiology. Heart Lung Circ. 21(4):231-3. 21889909
Alozie A, Westphal B, Yerebakan C, Steinhoff G. (2012). Transient ischaemic attack due to the lead of an implantable defibrillator in the left heart. Interact Cardiovasc Thorac Surg. 14(1): 128-30. 22108939
Divchev D, Kische S, Paranskaya L, Schneider H, Rehders T, Ortak J, Akin I, Turan G,Turan CH, Steinhoff G, Noldge-Schomburg G, Nienaber CA, Ince H. (2012). In-hospital outcome of patients with severe mitral valve regurgitation classified as inoperable and treated with the MitraClip R device. J Interv Cardiol. 180-189. 22188385
Donndorf P, Kaminski A, Tiedemann G, Kundt G, Steinhoff G. (2012). Validating intramyocardial bone marrow stem cell therapy in combination with coronary artery bypass grafting, the PERFECT Phase III randomized multicenter trial: study protocol for a randomized controlled trial. Trials. 13:99. 22747980
Donndorf P, Kühn F, Vollmar B, Rösner J, Liebold A, Gierer P, Steinhoff G, Kaminski A. (2012). Comparing microvascular alterations during minimal extracorporeal circulation and conventional cardiopulmonary bypass in coronary artery bypass graft surgery: A prospective, randomized study. J Thorac Cardiovasc Surg. 144(3):677-83. 22698563
Donndorf P, Steinhoff G. (2012). CD133-Positive Cells for Cardiac Stem Cell Therapy: Current Status and Outlook. Adv Exp Med Biol. 777: 215-227. 23161085
Donndorf P, Strauer BE, Steinhoff G. (2012). Update on cardiac stem cell therapy in heart failure. Curr Opin Cardiol. 27(2): 154-60. 22249215
Hirano K, Wagner K, Mark P, Pittermann E, Gäbel R, Furlani D, Li W, Vollmar B, Yamada T, Steinhoff G, Ma N. (2012). Erythropoietin attenuates the sequels of ischemic spinal cord injury with enhanced recruitment of CD34(+) cells in mice. J Cell Mol Med. 16(8):1792-802. 22145921
Klopsch C, Kuhlmann HC, Barth FG. (2012). Airflow elicits a spider s jump towards airborne prey. I. Airflow around a flying blowfly. J R Soc Interface. 9(75):2591-2602. 22572032
Klopsch C, Steinhoff G. (2012). Tissue-engineered devices in cardiovascular surgery. Eur Surg Res. 49(1): 44-52.  22813649
Liu Y, Ye X, Mao L, Cheng Z, Yao X, Jia X, Mao D, Ou L, Li Z, Che Y, Liu N, Steinhoff G, Liu L, Kong D. (2012).   Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction. Cardiovasc Res; 97(2): 208-18. 23066088
Ludwig M, Steinhoff G, Li J. (2012). The regenerative potential of angiotensin AT2 receptor in cardiac repair. Can J Physiol Pharmacol. 90(3): 287-93. 22364522
Zhang Y, Li W, Ou L, Wang W, Delyagina E, Lux C, Sorg H, Riehemann K, Steinhoff G, Ma N. (2012). Targeted delivery of human VEGF gene via complexes of magnetic nanoparticle-adenoviral vectors enhanced cardiac regeneration. Plos One. 7(7):e39490. 22844395
   

2011

PubMed-ID

Steinhoff G (Herausgeber)
Regenerative Medicine – from protocol to patient
Springer Netherlands, 1032 Seiten, ISBN-13: 978-9048190744 , erschienen: Januar 2011

Sammelband

 
Delyagina E, Li W, Ma N, Steinhoff G.
Magnetic targeting strategies in gene delivery.
Nanomedicine (Lond). 2011 Nov;6(9):1593-604.
22077463
Donndorf P, Kundt G, Kaminski A, Yerebakan C, Liebold A, Steinhoff G, Glass A.
Intramyocardial bone marrow stem cell transplantation during coronary artery bypass surgery: A meta-analysis.
J Thorac Cardiovasc Surg. 2011 Oct;142(4):911-20
21376346
Donndorf P, Westphal B, Steinhoff G.
Early stenotic prosthesis failure after implantation of a stentless porcine aortic valve prosthesis.
Interact Cardiovasc Thorac Surg. 2011 Sep;13(3):348-9.
21712349

Furlani D, Donndorf P, Westien I, Ugurlucan M, Pittermann E, Wang W, Li W, Vollmar B, Steinhoff G, Kaminski A, Ma N.
HMGB-1 induces c-kit(+) cell microvascular rolling and adhesion via both toll-like receptor-2 and toll like receptor-4 of endothelial cells.
J Cell Mol Med. 2011. 16(5):1094-105.

21762373
Gaebel R, Furlani D, Sorg H, Polchow B, Frank J, Bieback K, Wang W, Klopsch C, Ong LL, Li W, Ma N, Steinhoff G.
Cell origin of human mesenchymal stem cells determines a different healing performance in cardiac regeneration.
PLoS One. 2011 Feb 10;6(2):e15652.  free full text
21347366
Gaebel R, Ma N, Liu J, Guan J, Koch L, Klopsch C, Gruene M, Toelk A, Wang W, Mark P, Wang F, Chichkov B, Li W, Steinhoff G.
Patterning human stem cells and endothelial cells with laser printing for cardiac regeneration.
Biomaterials. 2011 Dec;32(35):9218-30. Epub 2011 Sep 10.
21911255
Jungebluth P, Luedde M, Ferrer E, Luedde T, Vucur M, Peinado VI, Go T, Schreiber C, Richthofen MV, Bader A, Haag J, Darsow KH, Bartel SJ, Lange HA, Furlani D, Steinhoff G, Macchiarini P.
Mesenchymal stem cells restore lung function by recruiting resident and non-resident proteins.
Cell Transplant. 2011 Mar 7. 20(10):1561-74.
21396162
Kaminski A, Klopsch C, Mark P, Yerebakan C, Donndorf P, Gaebel R, Eisert F, Hasken S, Kreitz S, Glass A, Jockenhoevel S, Ma N, Kundt G, Liebold A, Steinhoff G.
Autologous Valve Replacement – CD133+ Stem Cell-plus-Fibrin Composite based Sprayed Cell Seeding for Intra-Operative Heart Valve Tissue Engineering.
Tissue Eng Part C Methods. 2011 Mar;17(3):299-309
20868207
Klopsch C, Donndorf P, Kaminski A, Ma N, Steinhoff G.
Zellquellen für kardiovaskuläres Tissue Engineering [Cell sources for cardiovascular tissue engineering.]
Chirurg. 2011 Apr;82(4):295-302.
German. full text als PDF (900 kb, nur für nichtkommerzielle Zwecke)
21424292
Nesselmann C, Kaminski A, Steinhoff G.
Cardiac stem cell therapy : Registered trials and a pilot study in patients with dilated cardiomyopathy.
Herz. 2011 Mar;36(2):121-134.
21424348
Strauer BE, Steinhoff G.
10 years of intracoronary and intramyocardial bone marrow stem cell therapy of the heart: from the methodological origin to clinical practice.
J Am Coll Cardiol. 2011 Sep 6;58(11):1095-104. Review.
21884944
Tiedemann G, Sethe S. (2011). Regulatory Frameworks for Cell and Tissue Based Therapies in Europe and the USA, in: „Regenerative Medicine – from protocol to patient“, Ed: Gustav Steinhoff, Springer Netherlands.  
Tiedemann G, Wagner A.
RegMed-Regularien im Praxistest: Herausforderungen und Hemmnisse der Translation
Regenerative Medizin, Heft 1/2011: 21-25
 

Tiedemann G, Wagner A.
Regenerative Medizin: Potenziale eines ressourcenorientierten Behandlungsprinzips für (Verschleiß-)Krankheiten im Alter
B&G Bewegungstherapie und Gesundheitssport, 2.2011: 70-73

 
Wang W, Li W, Ou L, Flick E, Mark P, Nesselmann C, Lux CA, Gatzen HH, Kaminski A, Liebold A, Lützow K, Lendlein A, Li RK, Steinhoff G, Ma N. (2011). Polyethylenimine-mediated gene delivery into human bone marrow mesenchymal stem cells from patients. J Cell Mol Med. 2011 Sep; 15(9): 1989-98. 20629995
Yerebakan C, Kaminski A, Westphal B, Donndorf P, Glass A, Liebold A, Stamm C, Steinhoff G.
Impact of preoperative left ventricular function and time from infarction on the long-term benefits after intramyocardial CD133(+) bone marrow stem cell transplant.
J Thorac Cardiovasc Surg. 2011 Jun 9. [Epub ahead of print]
21664627
Yerebakan C, Westphal B, Bayraktar S, Alozie A, Liebold A, Steinhoff G. Uncomplicated prior right ventricular perforation due to a pacemaker lead - an incidental finding during coronary artery bypass surgery. Wien Med Wochenschr. 2011 Dec; 161(23-24): 578-9.
 
22223260
   

2010

PubMed-ID

Curato C, Slavic S, Dong J, Skorska A, Altarche-Xifró W, Miteva K, Kaschina E, Thiel A, Imboden H, Wang J, Steckelings U, Steinhoff G, Unger T, Li J.
Identification of non-cytotoxic and IL-10-producing CD8+AT2R+ T cell population in response to ischemic heart injury.
J Immunol. 2010 Nov 15;185(10):6286-93.
20935205
Delyagina E, Li W, Schade A, Kuhlo AL, Ma N, Steinhoff G.
Low molecular weight polyethylenimine conjugated to magnetic nanoparticles as a vector for gene delivery.
American Institute of Physics (AIP) Proceedings Series / 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, 2010; 1311: 479-484.
 
Donndorf P, Kaminski A, Steinhoff G, Liebold A.
Transvalvular intramyocardial bone marrow stem cell transplantation in combination with videoscopic mitral valve repair.
Interact Cardiovasc Thorac Surg. Dec 2010; 11: 806 - 808.
20829387
Kaminski A, Donndorf P, Klopsch C, Steinhoff G.
Surgical intramyocardial stem cell therapy for chronic ischemic heart failure
Herz, 2010 Aug;35(5):324-33. German
20625690
Kasten A, Müller P, Bulnheim U, Groll J, Bruellhoff K, Beck U, Steinhoff G, Möller M, Rychly J.
Mechanical integrin stress and magnetic forces induce biological responses in mesenchymal stem cells which depend on environmental factors.
J Cell Biochem. Dec 2010; 111(6): 1586-97
21053275
Koch, L; Kuhn, S; Sorg, H; Gruene,M; Schlie, S; Gaebel, G; Polchow, B; Reimers, R; Stoelting, S; Ma, N; Vogt, P; Steinhoff, G; Chichkov, BN
Laser Printing of Skin Cells and Human Stem Cells
Tissue Eng Part C Methods.  2010 Oct;16(5):847-54
19883209
Nesselmann C, Li W, Ma N, Steinhoff G.
Stem cell-mediated neovascularization in heart repair.
Therapeutic Advances in Cardiovascular Disease, 2010; 4: 27-42. (Review)
20042449
Ong L, Li W, Oldigs JK, Kaminski A, Gerstmayer B, Piechaczek C, Wagner W, Li RK, Ma N, Steinhoff G.
Hypoxic/normoxic preconditioning increases endothelial differentiation potential of human bone marrow CD133+ cells
Tissue Eng Part C Methods. 2010 Oct;16(5):1069-81.
20073989
Ou L, Li W, Liu Y, Zhang Y, Jie S, Kong D, Steinhoff G, Ma N.
Animal models of cardiac disease and stem cell therapy.
Open Cardiovasc Med J. 2010 Nov 26;4:231-9.
21258568

Ou L, Li W, Zhang Y, Wang W, Liu J, Sorg H, Furlani D, Gäbel R, Mark P, Klopsch C, Wang L, Lützow K, Lendlein A, Wagner K, Klee D, Liebold A, Li RK, Kong D, Steinhoff G, Ma N.
Intracardiac injection of matrigel induces stem cell recruitment and improves cardiac functions in a rat myocardial infarction model
Journal of cellular and molecular medicine, 2010 May 14.

20477905
Shen J, Fu X, Ou L, Zhang M, Guan Y, Wang K, Che Y, Kong D, Steinhoff G, Li W, Yu Y, Ma N.
Construction of ureteral grafts by seeding urothelial cells and bone marrow mesenchymal stem cells into polycaprolactone-lecithin electrospun fibers.
The International Journal of Artificial Organs, 2010; 33(3): 161-170.
20383857
Wagner W, Bork S, Lepperdinger G, Joussen S, Ma N, Strunk D, Koch C.
How to track cellular aging of mesenchymal stromal cells.
Aging, 2010 Apr;2(4): 224-30
20453259
Wang W, Li W, Ong LL, Furlani D, Kaminski A, Liebold A, Lützow K, Lendlein A, Wang J, Li RK, Steinhoff G, Ma N.
Localized SDF-1alpha gene release mediated by collagen substrate induces CD117+ stem cell homing.
Journal of Cellular and Molecular Medicine, 2010; 14: 392-402.
19413887

Wang W, Li W, Ou L, Flick E, Mark P, Nesselmann C, Lux CA, Gatzen HH, Kaminski A, Liebold A, Lützow K, Lendlein A, Li RK, Steinhoff G, Ma N.
Polyethylenimine-mediated gene delivery into human bone marrow mesenchymal stem cells from patients 
Journal of Cellular and Molecular Medicine, Jul 13, 2010

20629995
Yerebakan C, Klopsch C, Niefeldt S, Zeisig V, Vollmar B, Liebold A, Sandica E, Steinhoff G.
Acute and chronic response of the right ventricle to surgically induced pressure and volume overload - an analysis of pressure-volume relations
Interact Cardiovasc Thorac Surg. 2010 Apr;10(4):519-25.
20089680
Yerebakan C; Steinhoff G; and Skrabal CA
Papillary fibroelastoma of the left heart with multiple origins?
Interactive CardioVascular and Thoracic Surgery, Nov 2010; 11: 677 - 678.
20962168
   

2009

PubMed-ID

Cevirme, D; Yerebakan, C; Bayraktar, S; Sunar, H
Cardiac hydatid cyst of the interatrial septum
Wien Med Wochenschr, Jan 2009; 159(17-18): 470-2
19823794
Emmrich, S; Wang, W; John, K; Li, W; Pützer, BM
Antisense gapmers selectively suppress individual oncogenic p73 splice isoforms and inhibit tumor growth in vivo
Molecular Cancer, 2009; 8: 61
19671150
Flick, E; Belski, A; Li, W; Steinhoff, G; Gatzen, HH
Magnetic microactuator for controlling nanoparticles in gene delivery applications
IEEE Transctions on Magnetics, 2009; 45(10), 4869-4872
 
Furlani, D; Li, W; Pittermann, E; Klopsch, C; Wang, L; Knopp, A; Jungebluth, P; Thedinga, E; Havenstein, C; Westien, I; Ugurlucan, M; Li, RK; Ma, N; Steinhoff, G
A transformed cell population derived from cultured mesenchymal stem cells has no functional effect after transplantation into the injured heart.
Cell Transplant. 2009;18(3):319-31
 19558780
Furlani, D; Ugurlucan, M; Ong, L; Bieback, K; Pittermann, E; Westien, I; Wang, W; Yerebakan, C; Li, W; Gaebel, R; Li, RK; Vollmar, B; Steinhoff, G; Ma, N
Is the intravascular administration of mesenchymal stem cells safe? Mesenchymal stem cells and intravital microscopy.
Microvasc Res. 2009 May;77(3):370-6.
19249320
Gäbel, R; Klopsch, C; Furlani, D; Yerebakan, C; Li, W; Ugurlucan, M; Ma, N; Steinhoff, G
Single high-dose intramyocardial administration of erythropoietin promotes early intracardiac proliferation, proves safety and restores cardiac performance after myocardial infarction in rats.
Interact Cardiovasc Thorac Surg. 2009 Jul;9(1):20-5; discussion 25
 19380336
Klopsch, C; Furlani, D; Gäbel, R; Li, W; Pittermann, E; Ugurlucan, M; Kundt, G; Zingler, C; Titze, U; Wang, W; Ong, LL; Wagner, K; Li, RK; Ma, N; Steinhoff, G
Intracardiac injection of erythropoietin induces stem cell recruitment and improves cardiac functions in a rat myocardial infarction model.
J Cell Mol Med. 2009 Apr;13(4):664-79
19449462
Lux, CA; Koschinski, A; Dersch, K; Husmann, M; Bhakdi, S
Hypersusceptibility of neutrophil granulocytes towards lethal action of free fatty acids contained in enzyme-modified atherogenic low density lipoprotein
Atherosclerosis. 2009 Nov;207(1):116-22.
19423111
Sandica, E; Hesse, C; Steinhoff, G; Peuster, M
Open Heart Surgery for a Very-Low-Weight (660 g) Premature Infant.
Pediatr Cardiol. 2009 Jan;30(1):74-6.
18584236
Tu-Rapp, H; Pu, L; Marques, A; Kulisch, C; Yu, X; Gierer, P; Ibrahim, S M; Vollmar,B
Genetic control of leukocyte-endothelial cell interaction in collagen-induced arthritis
Ann Rheum Dis. 2009 Feb 12.
19218235
Ugurlucan, M; Yerebakan, C; Furlani, D; Ma, N; Steinhoff, G
Cell sources for cardiovascular tissue regeneration and engineering.
Thorac Cardiovasc Surg. 2009 Mar;57(2):63-73. Epub 2009 Feb 24. Review
19241306
Wang, W; Li, W; Ong, LL; Lutzow, K; Lendlein, A; Furlani, D; Gäbel, R; Kong, D; Wang, J; Li, RK; Steinhoff, G; Ma, N
Localized and sustained SDF-1 gene release mediated by fibronectin films: A potential method for recruiting stem cells.
Int J Artif Organs. 2009 Mar;32(3):141-9.
19440989
Wang, Y; Kong, W; Song, Y; Duan, Y; Wang, L; Steinhoff, G; Kong, D; Yu, Y
Polyamidoamine Dendrimers with a Modified Pentaerythritol Core Having High Efficiency and Low Cytotoxicity as Gene Carriers
Biomacromolecules, 2009 Mar 9;10(3):617-22.
19215068
Yerebakan, C; Klopsch, C; Prietz, S; Boltze, J; Vollmar, B; Liebold, A; Steinhoff, G; Sandica, E
Pressure-volume loops: feasible for the evaluation of right ventricular function in an experimental model of acute pulmonary regurgitation?
Interact Cardiovasc Thorac Surg. 2009 Aug;9(2):163-8.
19470501
Yerebakan, C; Liebold, A; Steinhoff, G; Skrabal, CA
Papillary fibroelastoma of the aortic wall with partial occlusion of the right coronary ostium.
Ann Thorac Surg. 2009 Jun;87(6):1953-4
19463638
Yerebakan, C; Sandica, E; Prietz, S; Klopsch, C; Ugurlucan, M; Kaminski, A; Abdija, S; Lorenzen, B; Boltze, J; Nitzsche, B; Egger, D; Barten, M; Furlani, D; Ma, N; Vollmar, B; Liebold, A; Steinhoff, G
Autologous Umbilical Cord Blood Mononuclear Cell Transplantation Preserves Right Ventricular Function in a Novel Model of Chronic Right Ventricular Volume Overload
Cell Transplant. 2009;18(8):855-68
19500473

Yerebakan, C; Ugurlucan, M; Bayraktar, S; Bethea, BT; Conte JV
Effects of inhaled nitric oxide following lung transplantation
J Card Surg. 2009 May-Jun; 24(3):269-74

19438780
Yerebakan, C; Ugurlucan, M; Kaminski, A; Westphal, B; Liebold, A; Steinhoff, G
Autologous stem cell therapy with surgical myocardial revascularization - The Rostock University experience
Anadolu Kardiyol Derg, Dec 2009; 9(6): 457-64
19965315
Yerebakan, C; Westphal, B; Kröger, JC; Steinhoff, G
Traumatic arteriovenous fistula of the internal mammary vessels
Thorac Cardiovasc Surg. 2009 Oct;57(7):422-4.
19795332
Yerebakan, C; Westphal, B; Liebold, A; Steinhoff, G
Images in cardiovascular medicine. Local erosions of a bioprosthetic aortic valve cusp caused by towering ring suture knots too close to the valve.
Circulation. 2009 Jan 27;119(3):479
19171870
Yerebakan, C; Westphal, B; Steinhoff, G; Liebold, A
eComment: Freedom Solo stentless aortic bioprosthesis and postoperative thrombocytopenia--interpretation of available data and clinical consequences for surgeons.
Interact Cardiovasc Thorac Surg. 2009 Jan;8(1):73-4
19122155
Zhang, Y; Ou, L; Cheng, Z; Jia, X; Gao, N; Kong, D
Genetic modification of bone marrow mesenchymal stem cells with human CXCR4 gene and migration in vitro
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering, 2009 Jun;26(3):595-600
19634680
   

2008

PubMed-ID

Cheng, Z; Ou, L; Liu, Y; Li, F; Sun, B; Che, Y; Kong, D; Yu, Y; Steinhoff, G
Granulocyte colony-stimulating factor exacerbates cardiac fibrosis after myocardial infarction in a rat model of permanent occlusion.
Cardiovasc Res. 2008 Aug 18

1867639
Furlani, D; Klopsch, C; Gabel, R; Ugurlucan, M; Pittermann, E; Klee, D; Wagner, K; W, Li; Wang, W; Ong, LL; Nizze, H; Titze, U; Lutzow, K; Lendlein, A; Steinhoff, G; Ma, N
Intracardiac erythropoietin injection reveals antiinflammatory potential and improved cardiac functions detected by Forced Swim Test.
Transplant Proc. 2008 May;40(4):962
18555090
Kaminski, A; Ma, N; Donndorf, P; Lindenblatt, N; Feldmeier, G; Ong, LL; Furlani, D; Skrabal, C; Liebold, A; Vollmar, B; Steinhoff, G
Endothelial NOS is required for SDF-1alpha/CXCR4-mediated peripheral endothelial adhesion of c-kit+ bone marrow stem cells.
Lab Invest. 2008 Jan;88(1):58-69
18040270
Li, W; Ma, N; Ong, LL; Kaminski, A; Skrabal, C; Ugurlucan, M; Lorenz, P; Gatzen, HH; Lutzow, K; Lendlein, A; Putzer, BM; Li, RK; Steinhoff, G
Enhanced thoracic gene delivery by magnetic nanobead-mediated vector
J Gene Med. 2008 Aug:10(8):897-909
18481827
Muller, P; Bulnheim, U; Diener, A; Luthen, F; Teller, M; Klinkenberg, ED; Neumann, HG; Nebe, B; Liebold, A;Steinhoff, G; Rychly, J
Calcium phosphate surfaces promote osteogenic differentiation of mesenchymal stem cells.
J Cell Mol Med. 2008 Jan.-Feb; 12(1)
18366455
Nesselmann, C; Ma, N; Bieback, K; Wagner, W; Ho, A; Konttinen, YT; Zhang, H; Hinescu, ME; Steinhoff, G
Mesenchymal Stem Cells and Cardiac Repair.
J Cell Mol Med. 2008 Aug5.
18684237
Pompilio, G; Steinhoff, G; Liebold, A; Pesce, M; Alamanni, F; Capogrossi, MC; Biglioli, P
Direct minimally invasive intramyocardial injection of bone marrow-derived AC133+ stem cells in patients with refractory ischemia: preliminary results.
Thorac Cardiovasc Surg. 2008 Mar;56
18278680
Steinhoff, G
Regenerative Medicine - not just one step away.
J Cell Mol Med. 2008 Oct;12(5B):1794.
18684238
Steinhoff, G; Tiedemann, G; Thalheimer, M; Ho, AD
From basic research to the clinic. Regulations for preclinical and clinical studies with stem cells
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2008 Sep;51(9):973-9. German.
18773175
Yerebakan, C; Kaminski, A; Westphal, B; Kundt, G; Ugurlucan, M; Steinhoff, G; Liebold, A
Thrombocytopenia after aortic valve replacement with the Freedom Solo stentless bioprosthesis
Interact Cardiovasc Thorac Surg. 2008 Aug;7(4):616-20.
18505752
Yerebakan, C; Kaminski, A; Westphal, B; Liebold, A; Steinhoff, G
Autologous bone marrow stem cell therapy for the ischemic myocardium during coronary artery bypass grafting
Minim Invasive Ther Allied Technol. 2008;17(2):143-8
18465448
Yerebakan, C; Kaminski, A; Westphal, B; Liebold, A; Steinhoff, G
Kardiale Stammzelltherapie: Die Rostocker Studien
J Verbr Lebensm 2008; Suppl 1:77-82
 
   

 

Impressum Das RTC wird gefördert durch das BMBF und dem Land MV mit Mitteln aus den Strukturfonds der EU.